Influenza virus hemagglutinin stalk-based antibodies and vaccines
Identifieur interne : 000871 ( Main/Exploration ); précédent : 000870; suivant : 000872Influenza virus hemagglutinin stalk-based antibodies and vaccines
Auteurs : Florian Krammer [États-Unis] ; Peter Palese [États-Unis]Source :
- Current opinion in virology [ 1879-6257 ] ; 2013.
Abstract
Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Due to the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, e.g. chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.
Url:
DOI: 10.1016/j.coviro.2013.07.007
PubMed: 23978327
PubMed Central: 3804342
Affiliations:
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